BERNARD, Claude (1813-1878). Nouvelle fonction du foie considr comme organe producteur de matire sucre chez l'homme et les animaux . Paris: J.-B. Baillire, 1853. 4 o (255 x 206 mm). Wood-engraved text illustration. (Occasional light foxing.) Modern quarter maroon morocco, marbled sides, by Max Adjarian (padded with a quantity of modern paper). FIRST EDITION, MONOGRAPH ISSUE of Bernard's doctoral thesis in zoology. "Bernard began investigating the glycogenic function of the liver in the 1840s, publishing his first communication on the subject in 1848. In order to determine whether glycemia (sugar in the blood) is a normal or abnormal physiological phenomenon, Bernard conducted experiments in which series of animals were fed either starchy or meat diets, or in some cases were not fed at all for several days. He found sugar in blood samples taken from all of these groups, from which he concluded that glycemia results from a normal and constant metabolic process independent of food intake and that blood sugar must be produced by a source within the animal body. Upon further investigation, Bernard identified this source as the liver, demonstrating that it produces sugar and discharges it into the bloodstream. He termed this the 'glycogenic' function of the liver. A summary of his results was published in 1850. In 1853, as his thesis for the doctorate in science, Bernard published his Recherches sur une nouvelle fonction du foie consider comme organe producteur de matire sucre chez l'homme et les animaux ; this work was also issued in monograph form the same year, under a slightly modified title beginning Nouvelle fonction du foie " (Grolier Medicine ). Grmek 10; Grolier/Horblit 11a; Grolier Medicine 67a; Waller 970; Norman 200.
BERNARD, Claude (1813-1878). Nouvelle fonction du foie considr comme organe producteur de matire sucre chez l'homme et les animaux . Paris: J.-B. Baillire, 1853. 4 o (255 x 206 mm). Wood-engraved text illustration. (Occasional light foxing.) Modern quarter maroon morocco, marbled sides, by Max Adjarian (padded with a quantity of modern paper). FIRST EDITION, MONOGRAPH ISSUE of Bernard's doctoral thesis in zoology. "Bernard began investigating the glycogenic function of the liver in the 1840s, publishing his first communication on the subject in 1848. In order to determine whether glycemia (sugar in the blood) is a normal or abnormal physiological phenomenon, Bernard conducted experiments in which series of animals were fed either starchy or meat diets, or in some cases were not fed at all for several days. He found sugar in blood samples taken from all of these groups, from which he concluded that glycemia results from a normal and constant metabolic process independent of food intake and that blood sugar must be produced by a source within the animal body. Upon further investigation, Bernard identified this source as the liver, demonstrating that it produces sugar and discharges it into the bloodstream. He termed this the 'glycogenic' function of the liver. A summary of his results was published in 1850. In 1853, as his thesis for the doctorate in science, Bernard published his Recherches sur une nouvelle fonction du foie consider comme organe producteur de matire sucre chez l'homme et les animaux ; this work was also issued in monograph form the same year, under a slightly modified title beginning Nouvelle fonction du foie " (Grolier Medicine ). Grmek 10; Grolier/Horblit 11a; Grolier Medicine 67a; Waller 970; Norman 200.
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